MO947KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR (KIR) GENE DISTRIBUTION AND ALLOGRAFT KIDNEY FUNCTION

Abstract Background and Aims There is increasing evidence about the alloreactivity of natural killer (NK) cells after kidney transplantation. The inhibition activation cycles NK are mainly regulated by cell immunoglobulin-like receptors (KIRs) which may have extensive allelic polymorphisms within population. In this study, we examined KIR genes/genotypes in transplant recipients healthy subjects. We aimed to determine if there relations between certain genes graft function patients. Method Renal patients (n=131) controls (n=183) from same ethnic background with similar demographics were included. Transplant an obvious cause dysfunction presensitized excluded. Recruited classified as (GD) (n=38) or functioning (FG) (n=93) on basis allograft rejection dysfunction. Isolated DNA all participants typed for 16 specific primers using PCR. Patient groups compared clinical features. Results Significant differences observed KIR2DL3 KIR3DL1 that presented higher frequencies than (p=0.001 & p=0.006). Comparison GD FG revealed a protective association inhibitor gene KIR2DL1 (p=0.003, OR=0.148). Distribution remaining 15 rates genotype patterns not different among these patient groups. Conclusion more common was significantly frequent FG. suggest presence KIR2DL1, functions, might be associated favorable recipients.